Description
Gastric cancer remains one of the most common causes
of malignancy related death worldwide and continues to be
characterized by late presentation and a poor response to
treatment.
Helicobacter pylori(H. pylori) infection has been
implicated in gastric carcinogenesis, conferring a lifetime
relative risk of developing cancer of approximately 2-3. The
neoplastic cascade resulting from infection involves the
development of intestinal metaplasia and a corpus
predominant atrophic gastritis, as a result of genetically
determined host immune responses in concert with the
inflammatory stimuli resulting from infection. It is on the
background of these changes that dysplasia and invasive
carcinoma develop. The interplay of aetiological factors in
gastric cancer with H. pylori continues to be an area of
intense study.
