Description
Gout is a relatively common metabolic disorder of particular importance to the practising rheumatologist. The deposition of intra-articular crystals of monosodium urate monohydrate causes acute and chronic inflammation that can lead to long term joint damage. Identification of negatively bi-refringent crystals is the gold standard when making a definitive diagnosis. The relationship to hyperuricaemia is complex as raised levels of uric acid are not always present in the acute presentation. Successful treatment of this condition depends on a proper understanding of uric acid metabolism. It can reduce short-term morbidity and may prevent long term damage to the joint.
