Description
Systemic lupus erythematosis (SLE) is an autoimmune rheumatic disease with a complex multifactorial aetiology. Although the criteria for the classification of SLE are in widespread use, they are insufficient for diagnosis nor do they define outcome of SLE. SLE provides an excellent example of a disease whose effects need to be described in three ways. Firstly, disease activity needs to be defined by determining which of its
clinical features are potentially reversible. Secondly, permanent damage needs to be determined and lastly, the patient’s view of the impact of SLE on their health status and therefore, the degree of disability. This review describes the derivation and use of a range of indices designed to measure these three aspects of SLE.
