Description
Anaphylactic reactions during general anaesthesia are rare but potentially fatal. Prompt recognition of the reaction and implementation of effective resuscitation measures are of course the first priority. Subsequently, the agent responsible for the reaction must be identified, and safe alternatives found for use in subsequent anaesthetics. Fortunately, skin testing by, or with the advice of, an appropriately experienced colleague is usually a quick, safe and accurate method of achieving this. The timing of the onset of the reaction in relation to the administration of drugs is a strong indication of the drug(s) responsible. Neuro-muscular blocking agents are most frequently implicated in causing this type of reaction, which can also occur in response to NSAIDs, induction agents, antibiotics, plasma substitutes, blood products, latex and contrast media.
