Description
There is an increasing body f evidence which
supports an association between frontal lobe
dementia and Motor Neurone Disease (MND).
Talbot et al1
compared the results of
neuropsychological tests and PET scanning in three
groups of patients; normal controls, patients with
classic MND (cMND)and patients with MND and
fronto-temporal dementia (PTD/MND). They
demonstrated that the cMND patients had
neuropsychological and PET scan abnormalities
which were intermediate between those of the
ther two groups.It was suggested that cMND,
FTD/MND and FTD are the clinical manifestations
of a pathological continuum. This is supported by
the findings of Bergmann et al2
who demonstrated
that the histological appearances of cases of Pick’s
Disease, Motor Neurone Disease with dementia
and dementia of frontal lobe type are very similar.
