Description
Acute Myeloid Leukaemia has an incidence of 3-4 per 100,000 of the population in the UK.1 In 5-15% of cases there is evidence of prior exposure to chemotherapy or radiotherapy.2,3 Treatment – related AML frequently follows a prodrome of myelodysplasia and is often the result of damage to the pluripotent stem cell.4 There have been rare reports of de novo AML co-existing with monoclonal gammopathies or myeloproliferative disorders at presentation.5,6 There has been none to our knowledge of de novo AML occurring with non Hodgkins lymphoma, with extensive lymphadenopathy at presentation and without prior exposure to treatment. We describe such a case and suggest a common origin for both malignancies. We also provide an alternative hypothesis for the evolution of both diseases.
