Description
Critical review of: Annane D, Sebille V, Charpentier C. Effect of treatment with low doses of Hydrocortisone and Fludrocortisone on mortality in patients with Septic Shock. JAMA 2002; 288: 862-871.
Steroids in the treatment of sepsis have a long and controversial history. This significant paper bravely attempts to answer these questions. We have therefore asked 2 Intensivists, one of whom regularly uses steroids in sepsis and one who does not, to independently analyse this paper. Here are their conclusions:
