Effectiveness of antibiotic prophylaxis in critically ill adult patients: systematic review of randomised controlled trials

Author(s): Professor Hilary Humphreys

Description

D’Amico R, Pifferi S, Leonetti C, Torri V, Tinazzi A, Liberati A. Effectiveness of antibiotic
prophylaxis in critically ill adult patients: systematic review of randomised controlled trials. British
Medical Journal 1998; 316-1275-85.

An updated meta-analysis of trials involving selective decontamination of the digestive tract (SDD) was undertaken to determine the efficacy of this controversial approach to preventing respiratory infection and reducing mortality.