Description
Sarcoidosis, a systemic granulomatous disease,
has a worldwide distribution. It commonly affects
young adults and manifests with bilateral hilar
adenopathy, pulmonary infiltration, reticuloendothelial
involvement, eyes and skin lesions.
Cardiac, central nervous system, gastrointestinal,
and renal lesions are less frequent. Immunological
alterations include peripheral depression of delayedtype
hypersensitivity, imbalance of OK T4:T8
subsets, an influx of T4 helper cells and Th1
cytokines to the sites of granuloma formation,
hyperactivity of B-cells, and presence of immune
complexes.
