Description
Cushing’s syndrome is one of the most challenging topics in endocrinology. Until recently, the differential diagnosis of Cushing’s disease from ectopic ACTH production posed particular problems. Misdiagnosis may occur, as exemplified by the accompanying case report. This has now been largely resolved by the technique of inferior petrosal sinus sampling. The localisation and management of tumours ectopically producing ACTH, however, remains a difficult problem. Both anatomical and functional imaging techniques are required for tumour localisation.
